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Donating Plasma vs. Blood: What Is the Difference?

Blood and plasma products play an important role in life-saving procedures and treatments that occur at hospitals and medical centers every day. Both whole blood donations and plasma donations are vital to the success of modern medicine, but they have different side effects and preparation processes. This guide compares plasma versus whole blood donation—including side effects, the donation process, and recovery time—to help you decide which one is right for you.

Donating Plasma vs. Blood: What Is the Difference?

There are several differences between donating whole blood and plasma. The main difference is that whole blood donations occur only once a month, while plasma donations can occur twice a week. Another difference is that whole blood donations are made up of red blood cells, white blood cells, platelets, and plasma. Plasma, on the other hand, is essentially the fluid portion of your blood that contains water and clotting factors (antibodies).

Blood Plasma vs. Whole Blood Donation: Side Effects

While donating plasma is a safe, simple procedure with no significant side effects, donating whole blood can be slightly more uncomfortable. Both donations entail a needle insertion into the arm, but donating whole blood can take longer and be slightly more uncomfortable than donating plasma.

Blood Plasma vs. Whole Blood Donation: Frequencies

Plasma donation frequencies are more frequent than whole blood donation frequencies. Whole blood donors can donate whole blood once every eight weeks, while plasma donors can donate plasma twice a week. As a plasma donor, you can help provide a constant supply of plasma to those who need it.

Blood Plasma vs. Whole Blood Donation: Donation Process

The process for donating whole blood and plasma is similar. Both require a blood draw, but plasma donation draws are much quicker than whole blood donation draws. Whole blood donations are also made on-site at a blood drive or donation center, while plasma donations are made in a sterile, controlled environment.

Blood Plasma vs. Whole Blood Donation: Donation Time

The time required to donate plasma is significantly less than the time required to donate whole blood. Whole blood donations take approximately 10-12 minutes, while plasma donations take approximately 90 minutes.

Blood Plasma vs. Whole Blood Donation: Recovery Time

While plasma donation recovery time is quicker than a whole blood donation, both plasma and whole blood donors typically feel fine after a donation, though they may experience lightheadedness or a pinching sensation in the arm.

Blood Plasma vs. Whole Blood Donation: Compensation

Compensation can also differ between whole blood and plasma donations. Whole blood donors earn $30, and plasma donors earn $30-$60, with the additional reimbursement depending on how often you donate. You can earn up to $300 a year by donating blood plasma.

Conclusion

While both whole blood and plasma donations are vital to different levels of medicine, there are significant differences between the donation processes and frequency of donations. Plasma donation frequency is much more frequent, and the donation process is much less uncomfortable than whole blood donation. However, plasma donations take place in a sterile environment, while whole blood donations occur in a donation center.

Donate at the nearest plasma center today! Come to thplasma! We are a different type of plasma-donation company—steeped in community, driven by innovation, and guided by genuine care for our donors and employees.